Research
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In addition to serving as a national resource for HIV-related research, CNTN is affiliated with a number of ongoing research programs at each of the participating sites. Below are examples of research projects that utilize CNTN resources. |
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Immunophilins in the Neuroglial Response to HIV Infection Cristian Achim, M.D., Ph.D. |
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Agency: Award Number: |
The goal of this project is to study the association between immunophilins and markers of neurodegeneration in HIV-infected patients and test the hypothesis that IP ligand treatments may protect against HIV-associated axonal degeneration mediated by chemokines. |
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TLR Gene Expression in HIV Neurocognitive Disorder Cristian Achim, M.D., Ph.D. |
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Agency: Award Number: |
To examine the potential relationship between TLR3 and 4 gene expression and exposure to HIV. |
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Multimodel Correlation of Imaging Markers and Neuropathogenesis of NeuroAIDS Jacopo Annese, Ph.D. |
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Agency: Award Number: |
To conduct a multi-parametric examination of neuropathogenetic phenomena that are induced by HIV infection, correlating markers of the disease revealed by different imaging modalities (in vivo and ex vivo) with those localized by specific histological methods to improve our understanding of HIV neuropathogenesis towards the earliest detection by non-invasive means of neurological signs and response to treatment. |
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Multimodal Analysis of HIV-Related White Matter Neuropathology: Correlation between MRI and 3-dimensional (3D) Quantitative Histology Jacopo Annese, Ph.D. |
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Agency: Award Number: P30MH062512 (Developmental Award) |
To examine histologically whole hemispheres from brains of individuals affected by the human immunodeficiency virus (HIV) who have been well characterized through Magnetic Resonance Imaging (MRI) and behavioral studies. |
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Genetics of Monooxygenase Activity & Methamphetamine-Related Brain Injury in HIV Mariana Cherner, Ph.D. |
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Agency: Award Number: |
To examine the relationship between CYP2D6 and FMO3 genotypes and neuropathologic changes observed in brain tissue from METH dependent subjects who died with AIDS. |
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Role of CYP2D6 in Cognitive and Motor Impairments Associated with Methamphetamine Dependence Mariana Cherner, Ph.D. |
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Agency: Award Number: P30MH062512 (Developmental Award) |
To test the hypothesis that those meth users who develop NP impairments are more likely to be represented by phenotypes with deficient CYP2D6 alleles (PM and IM) than those who are NP normal, despite comparable exposure to meth. |
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Role of Epigenetic Alterations in the Latency of HIV in the Human Brain Paula Desplats, Ph.D. |
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Agency: Award Number: P30MH062512 (Developmental Award) |
This study will help determine the role of epigenetic alterations in the regulation of the latency of HIV in the human brain. |
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ARC: Biomarkers/NC Impairment Igor Grant, M.D. |
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Agency: Award Number: |
An administrative supplement to evaluate the relationship between biomarkers assessed in various fluids/compartments and the development of, or recovery from, HIV-associated neurocognitive disorders. |
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Mechanisms of Neuroprotection in HIV Encephalitis Eliezer Masliah, M.D. |
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Agency: Award Number: |
To investigate the role of alterations in CDK5 signaling pathway in the molecular mechanisms of synapto-dendritic damage triggered by HIV proteins, and to determine the involvement of the CDK5 signaling pathway in the mechanisms of defective neurogenesis triggered by HIV proteins. |
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A Multi-System Study of HIV Neuropathogenesis: Genetics-Neuropathology-Behavior David Moore, Ph.D. |
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Agency: Award Number: |
The goal of this study is to 1) identify associations between host genetic susceptibility loci and neuropathological intermediate phenotypes (NIPs) as measured via quantitative immunohistochemistry (IHC), and 2) determine the linear causative relationship between genetic susceptibility loci, NIPs, and neurocognitive impairment. |
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Mannose Binding Lectin in Neuroinflammation and NeuroAIDS Kumud K. Singh, Ph.D. |
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Agency: NIH/HNRC Award Number: P30MH062512 (Developmental Award) |
To analyze gene expression in PBMC samples derived from HIV-infected individuals with and without neurocognitive decline. |
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Cerebral Vasomotor Effects on B-amyloid Deposition in the HIV-infected Brain Virawudh Soontornniyomkij, Ph.D. |
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Agency: NIH/HNRC Award Number: P30MH062512 (Developmental Award) |
To study postmortem tissues from the frontal cortex, basal forebrain, and rostral pons of 40 HIV-infected patients and 10 HIV-seronegative controls, by immunohistochemistry to identify AB40 and AB42 deposits, neuronal tau pathology, and p75 neurotrophin receptor- and calbindin-immunoreactive neurons. |
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Micro-RNA Profiling in Central Nervous System of Human Immunodeficiency Virus Infected Individuals Erick Tatro, Ph.D. |
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Agency: Award Number: P30MH062512 (Developmental Award) |
Utilize PCR-based arrays to assess a panel of 379 microRNAs and compare the miRNA expression in HIVinfected subjects with age-matched controls in the HNRC cohorts. |
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In Vivo Proton MRS Studies: Cerebral Injury in HIV Infection - Subcontract Michael Taylor, Ph.D. |
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Agency: Award Number: |
To examine the relationship of metabolic patterns, as measured by MRS, in CNTN subjects to levels of HIV RNA, immune activation, including chemokines, the CSF and peripheral compartments in response to potent antiretroviral therapy. This study will also correlate changes in regional metabolites and surrogate markers of disease to neurocognitive performance. |
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Gene Expression Analysis to Identify Biomarkers of HIV Associated Neurocognitive Disorders (HAND) Christopher Woelk, Ph.D. |
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Agency: Award Number: P30MH062512 (Developmental Award) |
To analyze gene expression in PBMC samples derived from HIV-infected individuals with and without HIV-associated neurocognitive disorders. |
