The 19th Conference on Retroviruses and Opportunistic Infections in Seattle, Washington on March 5-8, 2012 awards travel expenses to promising young investigators. Josue Perez-Santiago becomes the second HNRP affiliated investigator to win such an award (Dr. David Croteau previously won this award). The winning abstract is included below and utilized CNTN study generated data. The results suggest that methylation profiles could be used as a prognostic as well as a diagnostic tool for neurocognitive decline in HIV infection. DNA methylation may provide a rich source for biomarker development since, in addition to the repression of promoter activity, methylation can also indicate the repression of distal regulatory elements.
Perez-Santiago J, Plongthongkum N, Letendre S, Ellis R, Gouaux B, Moore D, LeBlanc S, Rajagopal N, Zhang K, Woelk C. (2012). DNA methylation correlates with neurological decline in HIV-infected individuals.