Newly Funded Grant - Cerebrospinal Fluid and Plasma Biomarkers of HIV-Related Neuropathology
Mr. Alex Bryant, a UCSD medical student, was recently awarded an HNRC Developmental Grant to measure an array of biomarkers in CSF and plasma samples from HIV-infected patients and evaluate their relationship to inflammation, gliosis, neuronal damage, and cerebrovascular disease in postmortem brain tissue and antemortem measures of neurocognitive impairment. Mr. Bryant is a trainee under the mentorship of CNTN Investigators Ron Ellis, M.D., Ph.D., Scott Letendre, M.D., and David Moore, Ph.D.
The First HIV/AIDS Generation Reaches Retirement Age
Newsweek published an article byon September 18, 2014, "The First HIV/AIDS Generation Reaches Retirement Age". The article covers many of the issues of an aging HIV infected population. These issues are the impetus of HNRP research focusing on prospective memory, adherence to medication, comorbid aging conditions such as diabetes and cardiovascular disease, and neurological conditions such as dementia.
Click Here to read the full article.
Josue Perez-Santiago Awarded CROI 2012 Young Investigator Award Using CNTN Data
The 19th Conference on Retroviruses and Opportunistic Infections in Seattle, Washington on March 5-8, 2012 awards travel expenses to promising young investigators. Josue Perez-Santiago becomes the second HNRP affiliated investigator to win such an award (Dr. David Croteau previously won this award). The winning abstract is included below and utilized CNTN study generated data. The results suggest that methylation profiles could be used as a prognostic as well as a diagnostic tool for neurocognitive decline in HIV infection. DNA methylation may provide a rich source for biomarker development since, in addition to the repression of promoter activity, methylation can also indicate the repression of distal regulatory elements.
Perez-Santiago J, Plongthongkum N, Letendre S, Ellis R, Gouaux B, Moore D, LeBlanc S, Rajagopal N, Zhang K, Woelk C. (2012). DNA methylation correlates with neurological decline in HIV-infected individuals.
CNTN Investigators Present at CROI 2012
The following were presented by CNTN investigators at the 19th Conference on Retroviruses and Opportunistic Infections in Seattle, Washington on March 5-8, 2012.
- Nathamu S, Adame A, Dumaop W, Gouaux B, Moore D, Masliah E, Singh K, and the HNRC Group. (2012). Lectin complement pathway activation is linked to immune complex deposition in HIV encephalitis.
- Nathamu S, Adame A, Dumaop W, Gouaux B, Moore D, Masliah, E, Singh K, and the HNRC Group. (2012). Increased expression of complement receptor 2 and ligand C3 deposition in HIV encephalitis: A potential link to innate and adaptive immune responses in NeuroAIDS.
- Perez-Santiago J, Plongthongkum N, Letendre S, Ellis R, Gouaux B, Moore D, LeBlanc S, Rajagopal N, Zhang K, Woelk C. (2012). DNA methylation correlates with neurological decline in HIV-infected individuals.
Erick Tatro Presents at ISNV and Receives Travel Award
The 11th International Symposium on NeuroVirology (ISNV)started on May 29, 2012 in New York, NY. The overall goal of the meeting is to provide investigators working in the field of neurovirology and related areas with leading edge information so that new preventative and therapeutic strategies effective against neurologic diseases associated with prions, HIV, and other viral and non-viral pathogens can be identified.
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